mesh cages 18 × 18 Search Results


95
Chem Impex International tentagel thiol resin
Tentagel Thiol Resin, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tentagel thiol resin - by Bioz Stars, 2026-08
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Chem Impex International protoporphyrin ix
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Protoporphyrin Ix, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pmc06901296-438-35-37?v=Chem+Impex+International
Average 95 stars, based on 1 article reviews
protoporphyrin ix - by Bioz Stars, 2026-08
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Chem Impex International materials 2 cl trityl chloride resin
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Materials 2 Cl Trityl Chloride Resin, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pmc12593409__ja5c13598_si_001-3-0-25?v=Chem+Impex+International
Average 95 stars, based on 1 article reviews
materials 2 cl trityl chloride resin - by Bioz Stars, 2026-08
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Chem Impex International trt gly oh
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Trt Gly Oh, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pmc03984053-109-2-6?v=Chem+Impex+International
Average 95 stars, based on 1 article reviews
trt gly oh - by Bioz Stars, 2026-08
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Chem Impex International palladium tetrakis
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Palladium Tetrakis, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pmc10421628-310-16-34?v=Chem+Impex+International
Average 95 stars, based on 1 article reviews
palladium tetrakis - by Bioz Stars, 2026-08
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90
Phifer Inc aluminum insect screen
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Aluminum Insect Screen, supplied by Phifer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/10__1603_slash_en12081-40-5-8?v=Phifer+Inc
Average 90 stars, based on 1 article reviews
aluminum insect screen - by Bioz Stars, 2026-08
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ANSYS inc hyper mesh v 11.0 ansys r 18.1 software
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Hyper Mesh V 11.0 Ansys R 18.1 Software, supplied by ANSYS inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pmc11795501-61-25-29?v=ANSYS+inc
Average 90 stars, based on 1 article reviews
hyper mesh v 11.0 ansys r 18.1 software - by Bioz Stars, 2026-08
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ANSYS inc 18.0 fluent mesh tool
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
18.0 Fluent Mesh Tool, supplied by ANSYS inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/ppr0260788-170-8-7?v=ANSYS+inc
Average 90 stars, based on 1 article reviews
18.0 fluent mesh tool - by Bioz Stars, 2026-08
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90
Avantor activated charcoal 18–35 mesh
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Activated Charcoal 18–35 Mesh, supplied by Avantor, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pm23278281-75-34-37?v=Avantor
Average 90 stars, based on 1 article reviews
activated charcoal 18–35 mesh - by Bioz Stars, 2026-08
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90
Phifer Inc mesh 0.011 diameter, 18 × 16 mesh count
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Mesh 0.011 Diameter, 18 × 16 Mesh Count, supplied by Phifer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/pmc11865819-133-6-8?v=Phifer+Inc
Average 90 stars, based on 1 article reviews
mesh 0.011 diameter, 18 × 16 mesh count - by Bioz Stars, 2026-08
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Phifer Inc aluminum 18×16 mesh, wire diameter 0.011′′
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Aluminum 18×16 Mesh, Wire Diameter 0.011′′, supplied by Phifer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mesh+cages+18+%C3%97+18/us09517433-428-6-12?v=Phifer+Inc
Average 90 stars, based on 1 article reviews
aluminum 18×16 mesh, wire diameter 0.011′′ - by Bioz Stars, 2026-08
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90
OVITO GmbH surface mesh modification 18
Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds <t>protoporphyrin</t> IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.
Surface Mesh Modification 18, supplied by OVITO GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds protoporphyrin IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.

Journal: The Journal of Biological Chemistry

Article Title: High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

doi: 10.1074/jbc.RA119.009951

Figure Lengend Snippet: Small molecules inhibit CGG RAN translation in multiple reading frames. A, structures of compounds used in B–H. B–F, compounds identified from screen as RAN translation inhibitors were independently reassessed for their activity in RRL in vitro translation assays. The indicated compounds were added at increasing doses to 30% RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs, and luminescence was measured relative to vehicle (DMSO) treatment. G and H, candidate compounds protoporphyrin IX and TMPyP4 were added at increasing concentrations to RRL reactions with AUG, +1CGGx100, or +2CGGx100-NLuc reporter mRNAs. Luminescence was measured relative to vehicle (DMSO) treatment. For all graphs, n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test.

Article Snippet: Independent validation of hits in RRL system The following compounds were purchased through Sigma Marketsite: cephalothin sodium (Sigma–Aldrich, C4520), rufloxacin HCl (Vitas-M Laboratory, Ltd., STK711124), rofecoxib (Sigma–Aldrich, MFCD00935806), alfuzosin HCl (Sigma–Aldrich, A0232), olanzapine (Sigma–Aldrich, O1141), protoporphyrin IX (Chem-Impex Int, Inc., 21661), pefloxacine mesylate (Selleck Chemicals, S1855), reserpine (Sigma–Aldrich, MFCD00005091), isoxicam (Sigma–Aldrich, MFCD000079374), phenazopyridine HCl (Sigma–Aldrich, MFCD00035347), parbendazole (Sigma–Aldrich, MFCD018910864), balsalazide disodium salt dihydrate (Key Organics/BIONET, KS-5216), efavirenz (Sigma–Aldrich, SML0536), oxiconazole nitrate (Key Organics/BIONET, KS-5288), sulfamethazine sodium salt (Sigma, S5637-25G), kenpaullone (Adooq Bioscience, A11220), propidium iodide (Sigma, P4170), BIX01294 HCl hydrate (Cayman Chemical, 13124), anthralin (Key Organics/BIONET, KS-5183), CP-31398 dihydrochloride hydrate (Tocris Bioscience, 3023), X80 (Sigma, X3629), amlexanox (Sigma, 68302-57-8).

Techniques: Activity Assay, In Vitro, Comparison

Small molecules inhibit C9RAN translation in all three reading frames. BIX01294 (A), anthralin (B), and protoporphyrin IX (C) were added at increasing concentrations to 30% RRL in vitro translation reactions with AUG-NLuc or GGGGCCx70 reporter mRNAs for all three reading frames, and luminescence was measured relative to vehicle (DMSO) control. D–F, selective inhibition of RAN translation of GGGGCCx70 and CGGx100 NLuc reporter mRNAs, relative to AUG-NLuc control, was confirmed by Western blotting against a C-terminal FLAG tag for the glycine-alanine (GA) and FMRPolyG (+1CGG) products, following incubation with BIX01294, anthralin, or protoporphyrin IX at the indicated doses. GAPDH was used as a loading control. For A–C, all graphs represent mean of n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test. M, mock; GA, glycine-alanine; GP, glycine-proline; GR, glycine-arginine.

Journal: The Journal of Biological Chemistry

Article Title: High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

doi: 10.1074/jbc.RA119.009951

Figure Lengend Snippet: Small molecules inhibit C9RAN translation in all three reading frames. BIX01294 (A), anthralin (B), and protoporphyrin IX (C) were added at increasing concentrations to 30% RRL in vitro translation reactions with AUG-NLuc or GGGGCCx70 reporter mRNAs for all three reading frames, and luminescence was measured relative to vehicle (DMSO) control. D–F, selective inhibition of RAN translation of GGGGCCx70 and CGGx100 NLuc reporter mRNAs, relative to AUG-NLuc control, was confirmed by Western blotting against a C-terminal FLAG tag for the glycine-alanine (GA) and FMRPolyG (+1CGG) products, following incubation with BIX01294, anthralin, or protoporphyrin IX at the indicated doses. GAPDH was used as a loading control. For A–C, all graphs represent mean of n = 3; error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test. M, mock; GA, glycine-alanine; GP, glycine-proline; GR, glycine-arginine.

Article Snippet: Independent validation of hits in RRL system The following compounds were purchased through Sigma Marketsite: cephalothin sodium (Sigma–Aldrich, C4520), rufloxacin HCl (Vitas-M Laboratory, Ltd., STK711124), rofecoxib (Sigma–Aldrich, MFCD00935806), alfuzosin HCl (Sigma–Aldrich, A0232), olanzapine (Sigma–Aldrich, O1141), protoporphyrin IX (Chem-Impex Int, Inc., 21661), pefloxacine mesylate (Selleck Chemicals, S1855), reserpine (Sigma–Aldrich, MFCD00005091), isoxicam (Sigma–Aldrich, MFCD000079374), phenazopyridine HCl (Sigma–Aldrich, MFCD00035347), parbendazole (Sigma–Aldrich, MFCD018910864), balsalazide disodium salt dihydrate (Key Organics/BIONET, KS-5216), efavirenz (Sigma–Aldrich, SML0536), oxiconazole nitrate (Key Organics/BIONET, KS-5288), sulfamethazine sodium salt (Sigma, S5637-25G), kenpaullone (Adooq Bioscience, A11220), propidium iodide (Sigma, P4170), BIX01294 HCl hydrate (Cayman Chemical, 13124), anthralin (Key Organics/BIONET, KS-5183), CP-31398 dihydrochloride hydrate (Tocris Bioscience, 3023), X80 (Sigma, X3629), amlexanox (Sigma, 68302-57-8).

Techniques: In Vitro, Inhibition, Western Blot, FLAG-tag, Incubation, Comparison

RAN translation inhibitors have varying effects on AUG-initiated repeat translation. A, schematic of NLuc reporter mRNAs used in 30% RRL in vitro translation assays, illustrating the position of the AUG start codons inserted upstream of the repeats, to drive translation in the indicated reading frames. The effect of anthralin (B), TMPyP4 (C), protoporphyrin IX (D), BIX01294 (E), and CP-31398 (F) on +1 and +2CGGx100 RAN translation, compared with AUG-initiated CGGx100 translation, measured in the presence of increasing concentrations of each small molecule. For B–F, values are relative to DMSO controls, and graphs represent the mean of n = 3. Error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test. 3xF, 3xFLAG tag.

Journal: The Journal of Biological Chemistry

Article Title: High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

doi: 10.1074/jbc.RA119.009951

Figure Lengend Snippet: RAN translation inhibitors have varying effects on AUG-initiated repeat translation. A, schematic of NLuc reporter mRNAs used in 30% RRL in vitro translation assays, illustrating the position of the AUG start codons inserted upstream of the repeats, to drive translation in the indicated reading frames. The effect of anthralin (B), TMPyP4 (C), protoporphyrin IX (D), BIX01294 (E), and CP-31398 (F) on +1 and +2CGGx100 RAN translation, compared with AUG-initiated CGGx100 translation, measured in the presence of increasing concentrations of each small molecule. For B–F, values are relative to DMSO controls, and graphs represent the mean of n = 3. Error bars, S.D. *, p < 0.05, two-way ANOVA with Dunnett's multiple-comparison test. 3xF, 3xFLAG tag.

Article Snippet: Independent validation of hits in RRL system The following compounds were purchased through Sigma Marketsite: cephalothin sodium (Sigma–Aldrich, C4520), rufloxacin HCl (Vitas-M Laboratory, Ltd., STK711124), rofecoxib (Sigma–Aldrich, MFCD00935806), alfuzosin HCl (Sigma–Aldrich, A0232), olanzapine (Sigma–Aldrich, O1141), protoporphyrin IX (Chem-Impex Int, Inc., 21661), pefloxacine mesylate (Selleck Chemicals, S1855), reserpine (Sigma–Aldrich, MFCD00005091), isoxicam (Sigma–Aldrich, MFCD000079374), phenazopyridine HCl (Sigma–Aldrich, MFCD00035347), parbendazole (Sigma–Aldrich, MFCD018910864), balsalazide disodium salt dihydrate (Key Organics/BIONET, KS-5216), efavirenz (Sigma–Aldrich, SML0536), oxiconazole nitrate (Key Organics/BIONET, KS-5288), sulfamethazine sodium salt (Sigma, S5637-25G), kenpaullone (Adooq Bioscience, A11220), propidium iodide (Sigma, P4170), BIX01294 HCl hydrate (Cayman Chemical, 13124), anthralin (Key Organics/BIONET, KS-5183), CP-31398 dihydrochloride hydrate (Tocris Bioscience, 3023), X80 (Sigma, X3629), amlexanox (Sigma, 68302-57-8).

Techniques: In Vitro, Comparison